The World of Pregnancy

Different Forms Of Genes Are Called…

The human genome is an entity that is quite complex and it frequently gets a mistakenly assigned primary role in heredity. Actually, the source from which everything begins is a small DNA component, known as the gene.

Different Forms Of Genes Are Called

Initially named by Mendel hereditary factor, the term of gene has been introduced later, along with Johnson`s definition who considered that the gene is a functional unit of the genotype which controls a phenotypically expressed character. However, later in 1975, Morgan has defined it as being the functional unit, recombination and mutation of the cellular genetic machinery. At present, the gene is considered as being a functional unit of mitochondrial and/or chromosomal DNA that is responsible for the synthesis of a specific protein.

The Particularities of Genes

Genes are disposed linearly and adjacent to the other genes in the neighborhood on a chromosome, and are chained with them forming linked groups along the mating axis of that specific chromosome. The gene isn`t in its chemically or morphologically delimited position from the other genes in the neighborhood, but the only way it`s delimited by other genes is its very own function, the genetic massage that is sent by the boundaries between the genes located on the same chromosome are strictly functional.

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The locus, the position that the gene on the chromosome occupies is fixed and identical for all the species` individuals. The locus might also be found on autosomes or sex chromosomes. The gene will set the order of amino acids in the molecule of the protein which determines a particular character. A gene is formed from around 900 – 1.500 nucleotides of the DNA chain (compounds that are formed from a heterocycle, a pentose as well as one or several phosphate groups).

Allele Genes

An allele is an alternative form under which the gene can be found on a locus given on a particular chromosome. It`s an alternative variant of a gene, its contrasting form, that influences the same character and occupies the same locus.

Polyaliele is a phenomenon by which a certain gene undergoes a few different mutations that have phenotypic effects that are varied, but also limited to the very same character (for instance, the shape of the face). It results different allele variants or multiple allele.

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The diversification of the gene in allelic variants is the result of a few processes: point mutations, unequal crossing-over deduction associated with the mutation of a gene, accidental deduction of a gene. Two or more alleles are known as allelomorphs when they have the very same locus on homologous chromosomes and when they are separated by meiosis, they produce distinct phenotypic effects in the expression of heterozygous character or phenotypic homozygote effects that are identical.

Example of polyalieles: The A1, A2, AB and 0 series of allele for the locus which determines the group of blood. A particular individual in a population group has only one of the allele genes in the population which is present in that population group, therefore that person will have a A1 or A2 or AB or 0 group of blood.

Genes which occur through the modification of normal genes are known as mutant genes. For most loci on human chromosomes there`s a standard gene variant and a mutant variant.

Homozygous & Heterozygous

We already established that allele genes can be normal or abnormal as well as identical or different. If the allele genes are identical, the genotype and the organism which posses them is homozygous, and if the alleles are different, genotype as well as the organism is heterozygous. On human chromosomes there`s a lot of loci, so every individual will be homozygous for some loci and heterozygous for other loci. The term hemizygot is used there are 2 distinct mutal alleles genes on a locus. For instance in men, an autosomal gene on chromosome X generally has no equivalent whatsoever on chromosome Y.

In the meiosis`s course, homozygotes might produce 1 type of gamet and are known as homogametics. Heterogamates and heterozygotes can produce 2 distinct types of games, each in proportion of 50% by segregation of allelic genes.

Dominant & Recessive

These are 2 models of the gene`s phenotypic expression. The gene and character which expresses phenotypically in heterozygotes are known as dominant genes and are generally capitalized. A particular gene that doesn`t occur phenotypically in heterozygotes and expresses itself just in a homozygous state is known as recessive gene and is written in small letters. For instance, in an individual with a genotype, the normal gene is the dominant gene, and the persons will have a normal phenotype, but they`ll carry the recessive gene, which is the abnormal one. Therefore, those who carry the dominant A gene and having a recessive gene N will be phenotypically ill. The recessive allele is manifested just when another similar allele gene is present, which results in homozygous persons with “aa” or “nn” genotype.

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Codominance is a concept defining the phenotypic manifestation of both allele genes in heterozygous. For instance, genes A and B of the ABO polio system which will determine the group of blood are dominant to the O gene and are codominant to each other, from this particular process resulting in persons with AB group of blood. The groups of blood A, B, and AB are generally determined by genotypes A0, B0 and AB.

Linkage & Crossing Over

Genetic chaining or linkage defines the process by which genes from the same chromosome tend to be grouped along with the respective chromosome through gametes from parents to children. Therefore, the neural genes found on the same chromosome don`t segregate into the meiosis and get transmitted together in the succession of generations forming a haplotype. Only genes that are close to each other suffer from this particular process. Genes that are at a larger distance on the same chromosome undergo the crossing-over process, their genetic link not being complete. Therefore, there are breaks occurring in chromatin level of homologous chromosomes followed by equal exchange of chromosomal fragments between homologous chromosomes with gene exchange between the 2, which results in a recombination of parental genes. The more chromosomes have a longer length, the more recombinations may happen. Sometimes a cross-over may occur that is uneven, which results in a recombination of aberrant genes, generating malformations and resulting in negative consequences which may lead to genetic illnesses.

Genes to Eukaryotes

Eukaryotic cells are very complex cells that are formed from a nucleus, membrane, cytoplasm as well as cell organisms. They all create human and animal tissues, and their genetic material is a lot more complex than that of prokaryotes (which are cells without a nuclear membrane and without most cellular organisms).  Linear molecules of double stranded DNA form with histone proteins, proteins which contribute in organizing the nucleosomes within DNA. Eukaryotic genes are unitary in replication, but non-unitary when it comes to transcription and translation. The genes aren`t indivisible, but are fragmented in introns, exons and unregistered regions.

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There`re 2 mechanisms of genetic regulation at eukaryotes:

  • Positive control: genes will only work in an inducer`s presence; it`s predominant.
  • Negative regulation: genes will only work the suppressor protein`s presence.

The transmission of characters from ancestors to offspring is based on the AND-ARN-protein principle. The cell nucleus organized in the chromosomes includes the DNA which divides before cell division because every cell needs to have a genetic material. Then the transcription of the genes selected with the precursor messenger RNA synthesis occurs, which include in its structure both info-bearing sequences and non-info sequences (exons and introns). Then the precursor RNA molecule will break down and separate the non-info sequences from the informational ones which will enter the mature messenger RNA structure. This will enter the ribosomal process of translation, which results in the synthesis of polypeptide chains based on info carried by the messenger RNA, chains which then will be processed resulting in very complex proteins.

Types of Genes

  • Genes that modify proteins (membrane proteins, signaling, regulatory, cytoskeletal);
  • Gene coding for functional products (enzymes, hormones).

The genes that encode proteins are of 2 types: ubiquitous and tissue. The first ones encode proteins that are involved in cellular processes which occur globally in all the organism`s cells and whose transcription is permanent. The tissues are generally present in each of the body`s cell but are only active in particular tissues. Local regulatory factors which are found in the 5` region of the gene coordinate transcription. These genes are split into: single genes, gene families and supergene families.

Also, there`re genetic sequences that don`t really have a fixed position in the genome, being able to change their locus, known as transposons or mobile genetic elements. They`re involved in the antibiotic resistance gene transfer from one particular bacterium to another one. They may be transcribed into RNA by serving as a template for DNA synthesis. Reverse transcription DNA products are known as retrotransposons., As soon as they get integrated into a specific gene sequence, they may suppress genetic mutations or gene activity.

Gene Families

It was found that in the genome there`re genes which although distinct as locus or size, have exons that are common. Thus, this will make these particular genes known as neomologous as they`re distinct as a position on the chromosomes, to encode related or identical proteins. The gene series with locuses results from serial mutations or duplicates in a wild or ancestral gene and is known as a multigenic family. Such examples are: HLA on chromosome 6, genes of the erythrocyte Rh system on chromosome , IgA1 on chromosome 14, IgK on chromosome 2.

The Relationship between Genes & Proteins

In the past, scientists thought that one single gene will encode one single protein. However, recent studies on gene structure found that it`s possible for a particular gene to encode a few proteins or several genes to encode one single protein. A gene is a discontinuous structure that includes exons and introns. The exon splicing process in the mature mRNA structure may be differentiated in such a way that the very same gene could encode distinct proteins. For instance, the calcitonin gene offers for the calcitonin thyroid hormone synthesis and calcitonin gene-related peptide sysnthesis, a neuromodulatory protein from the hypothalamus. The relationship between several genes and a protein was identified for polycatenin proteins like immunoglobulins, every peptide chain being made based on genetic info of gene families made from distinct genes which occupy distinct loci on the very same chromosome or even on distinct chromosomes. – Click here!

The genome, as the genome`s informational-active unit, is the basic hereditary unit, so in order to understand how the characters from parents to children are transmitted, it`s essential to know its functional and morphological characteristics.

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